Sodium-DNA for Bone Tissue Regeneration: An Experimental Study in Rat Calvaria
Identifieur interne : 000065 ( Main/Exploration ); précédent : 000064; suivant : 000066Sodium-DNA for Bone Tissue Regeneration: An Experimental Study in Rat Calvaria
Auteurs : Barbara Buffoli [Italie] ; Gaia Favero [Italie] ; Elisa Borsani [Italie] ; Ramon Boninsegna [Italie] ; Guido Sancassani [Italie] ; Mauro Labanca [Italie] ; Rita Rezzani [Italie] ; Pier Francesco Nocini [Italie] ; Massimo Albanese [Italie] ; Luigi Fabrizio Rodella [Italie]Source :
- BioMed Research International [ 2314-6133 ] ; 2017.
Abstract
Surgical techniques in dental and maxillofacial surgery request fast bone tissue regeneration, so there is a significant need to improve therapy for bone regeneration. Several studies have recently underlined the importance of nucleotides and nucleosides to increase cell proliferation and activity; in particular, the ability of polydeoxyribonucleotide (PDRN) to induce growth and activity of human osteoblasts was demonstrated. Sodium-DNA is the deoxyribonucleic acid (DNA) extracted from the gonadic tissue of male sturgeon and then purified, depolymerized, and neutralized with sodium hydroxide. To date, there are no evidences about the use of Sodium-DNA for bone tissue regeneration. Consequently, our question is about the efficacy of Sodium-DNA in bone healing. For testing the role of Sodium-DNA in bone healing we used a rat calvarial defect model. Sodium-DNA at different concentrations used alone or in association with Fibrin and/or Bio-Oss was used for healing treatments and the bone healing process was evaluated by histomorphometric and immunohistochemical analyses. Our results suggested a positive effect of Sodium-DNA in bone regeneration, providing a useful protocol and a model for the future clinical evaluation of its osteogenic properties.
Url:
DOI: 10.1155/2017/7320953
PubMed: 29082254
PubMed Central: 5610838
Affiliations:
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Mauro" sort="Labanca, Mauro" uniqKey="Labanca M" first="Mauro" last="Labanca">Mauro Labanca</name><affiliation wicri:level="1"><nlm:aff id="I1">Section of Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Rezzani, Rita" sort="Rezzani, Rita" uniqKey="Rezzani R" first="Rita" last="Rezzani">Rita Rezzani</name><affiliation wicri:level="1"><nlm:aff id="I1">Section of Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Interdipartimental University Center of Research “Adaption and Regeneration of Tissues and Organs (ARTO)”, University of Brescia, Brescia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Interdipartimental University Center of Research “Adaption and Regeneration of Tissues and Organs (ARTO)”, University of Brescia, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author><author><name sortKey="Nocini, Pier Francesco" sort="Nocini, Pier Francesco" uniqKey="Nocini P" first="Pier Francesco" last="Nocini">Pier Francesco Nocini</name><affiliation wicri:level="1"><nlm:aff id="I5">Section of Oral and Maxillofacial Surgery, Department of Surgery, University of Verona, Verona, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Oral and Maxillofacial Surgery, Department of Surgery, University of Verona, Verona</wicri:regionArea><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Albanese, Massimo" sort="Albanese, Massimo" uniqKey="Albanese M" first="Massimo" last="Albanese">Massimo Albanese</name><affiliation wicri:level="1"><nlm:aff id="I5">Section of Oral and Maxillofacial Surgery, Department of Surgery, University of Verona, Verona, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Oral and Maxillofacial Surgery, Department of Surgery, University of Verona, Verona</wicri:regionArea><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Rodella, Luigi Fabrizio" sort="Rodella, Luigi Fabrizio" uniqKey="Rodella L" first="Luigi Fabrizio" last="Rodella">Luigi Fabrizio Rodella</name><affiliation wicri:level="1"><nlm:aff id="I1">Section of Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Interdipartimental University Center of Research “Adaption and Regeneration of Tissues and Organs (ARTO)”, University of Brescia, Brescia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Interdipartimental University Center of Research “Adaption and Regeneration of Tissues and Organs (ARTO)”, University of Brescia, Brescia</wicri:regionArea><wicri:noRegion>Brescia</wicri:noRegion></affiliation></author></analytic><series><title level="j">BioMed Research International</title><idno type="ISSN">2314-6133</idno><idno type="eISSN">2314-6141</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Surgical techniques in dental and maxillofacial surgery request fast bone tissue regeneration, so there is a significant need to improve therapy for bone regeneration. Several studies have recently underlined the importance of nucleotides and nucleosides to increase cell proliferation and activity; in particular, the ability of polydeoxyribonucleotide (PDRN) to induce growth and activity of human osteoblasts was demonstrated. Sodium-DNA is the deoxyribonucleic acid (DNA) extracted from the gonadic tissue of male sturgeon and then purified, depolymerized, and neutralized with sodium hydroxide. To date, there are no evidences about the use of Sodium-DNA for bone tissue regeneration. Consequently, our question is about the efficacy of Sodium-DNA in bone healing. For testing the role of Sodium-DNA in bone healing we used a rat calvarial defect model. Sodium-DNA at different concentrations used alone or in association with Fibrin and/or Bio-Oss was used for healing treatments and the bone healing process was evaluated by histomorphometric and immunohistochemical analyses. Our results suggested a positive effect of Sodium-DNA in bone regeneration, providing a useful protocol and a model for the future clinical evaluation of its osteogenic properties. </p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Albanese, M" uniqKey="Albanese M">M. Albanese</name></author><author><name sortKey="Procacci, P" uniqKey="Procacci P">P. Procacci</name></author><author><name sortKey="Sancassani, G" uniqKey="Sancassani G">G. Sancassani</name></author><author><name sortKey="Nocini, P F" uniqKey="Nocini P">P. F. Nocini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alghamdi, A S" uniqKey="Alghamdi A">A. S. AlGhamdi</name></author><author><name sortKey="Shibly, O" uniqKey="Shibly O">O. Shibly</name></author><author><name sortKey="Ciancio, S G" uniqKey="Ciancio S">S. G. 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Martin</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Buffoli, Barbara" sort="Buffoli, Barbara" uniqKey="Buffoli B" first="Barbara" last="Buffoli">Barbara Buffoli</name></noRegion><name sortKey="Albanese, Massimo" sort="Albanese, Massimo" uniqKey="Albanese M" first="Massimo" last="Albanese">Massimo Albanese</name><name sortKey="Boninsegna, Ramon" sort="Boninsegna, Ramon" uniqKey="Boninsegna R" first="Ramon" last="Boninsegna">Ramon Boninsegna</name><name sortKey="Boninsegna, Ramon" sort="Boninsegna, Ramon" uniqKey="Boninsegna R" first="Ramon" last="Boninsegna">Ramon Boninsegna</name><name sortKey="Borsani, Elisa" sort="Borsani, Elisa" uniqKey="Borsani E" first="Elisa" last="Borsani">Elisa Borsani</name><name sortKey="Borsani, Elisa" sort="Borsani, Elisa" uniqKey="Borsani E" first="Elisa" last="Borsani">Elisa Borsani</name><name sortKey="Buffoli, Barbara" sort="Buffoli, Barbara" uniqKey="Buffoli B" first="Barbara" last="Buffoli">Barbara Buffoli</name><name sortKey="Favero, Gaia" sort="Favero, Gaia" uniqKey="Favero G" first="Gaia" last="Favero">Gaia Favero</name><name sortKey="Labanca, Mauro" sort="Labanca, Mauro" uniqKey="Labanca M" first="Mauro" last="Labanca">Mauro Labanca</name><name sortKey="Nocini, Pier Francesco" sort="Nocini, Pier Francesco" uniqKey="Nocini P" first="Pier Francesco" last="Nocini">Pier Francesco Nocini</name><name sortKey="Rezzani, Rita" sort="Rezzani, Rita" uniqKey="Rezzani R" first="Rita" last="Rezzani">Rita Rezzani</name><name sortKey="Rezzani, Rita" sort="Rezzani, Rita" uniqKey="Rezzani R" first="Rita" last="Rezzani">Rita Rezzani</name><name sortKey="Rodella, Luigi Fabrizio" sort="Rodella, Luigi Fabrizio" uniqKey="Rodella L" first="Luigi Fabrizio" last="Rodella">Luigi Fabrizio Rodella</name><name sortKey="Rodella, Luigi Fabrizio" sort="Rodella, Luigi Fabrizio" uniqKey="Rodella L" first="Luigi Fabrizio" last="Rodella">Luigi Fabrizio Rodella</name><name sortKey="Sancassani, Guido" sort="Sancassani, Guido" uniqKey="Sancassani G" first="Guido" last="Sancassani">Guido Sancassani</name><name sortKey="Sancassani, Guido" sort="Sancassani, Guido" uniqKey="Sancassani G" first="Guido" last="Sancassani">Guido Sancassani</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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